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Sunday, February 20, 2022 - 1:00PM
(0-1) Cincinnati Knights  23  vs
(1-0) Louisville Lightning  29
at Cardinal Stadium, Louisville, KY
Head To Head for:
Cincinnati vs Louisville
Box Score CIN @ LSV
Sunday, February 27, 2022 - 1:00PM
(1-1) Atlanta Flying Fleet  17  vs
(2-0) Louisville Lightning  28
at Cardinal Stadium, Louisville, KY
Head To Head for:
Atlanta vs Louisville
Box Score ATL @ LSV
Sunday, March 6, 2022 - 1:00PM
(3-0) Louisville Lightning  38  vs
(1-2) Louisiana Royals  26
at Caesars Superdome, New Orleans, LA
Head To Head for:
Louisville vs Louisiana
Box Score LSV @ LOU
Sunday, March 13, 2022 - 1:00PM
(4-0) Louisville Lightning  27  vs
(2-2) Chicago Maroons  24
at Soldier Field, Chicago, IL
Head To Head for:
Louisville vs Chicago
Box Score LSV @ CHI
Sunday, March 20, 2022 - 1:00PM
(4-1) St. Louis Brewers  27  vs
(5-0) Louisville Lightning  31
at Cardinal Stadium, Louisville, KY
Head To Head for:
St. Louis vs Louisville
Box Score STL @ LSV
Sunday, March 27, 2022 - 8:15PM
Sunday Night Football
(4-2) Carolina Reapers  13  vs
(6-0) Louisville Lightning  27
at Cardinal Stadium, Louisville, KY
Head To Head for:
Carolina vs Louisville
Box Score CAR @ LSV
Sunday, April 3, 2022 - 4:30PM
(7-0) Louisville Lightning  34  vs
(2-5) Colorado Cabras  31
at Canvas Stadium, Fort Collins, CO
Head To Head for:
Louisville vs Colorado
Box Score LSV @ COL
Sunday, April 10, 2022 - 1:00PM
(6-2) Louisiana Royals  23  vs
(7-1) Louisville Lightning  16
at Cardinal Stadium, Louisville, KY
Head To Head for:
Louisiana vs Louisville
Box Score LOU @ LSV
Sunday, April 17, 2022 - 8:15PM
Easter Sunday Game
(7-2) Louisville Lightning  33  vs
(2-7) Kansas City Buffaloes  36
at GEHA Field, Kansas City, MO
Head To Head for:
Louisville vs Kansas City
Box Score LSV @ KC
Sunday, April 24, 2022 - 1:00PM
(8-2) Louisville Lightning  31  vs
(4-6) Jacksonville Captains  24
at TIAA Bank Stadium, Jacksonville, FL
Head To Head for:
Louisville vs Jacksonville
Box Score LSV @ JAX
Monday, May 2, 2022 - 8:15PM
Monday Night Football
(5-5) Memphis Demons  27  vs
(8-3) Louisville Lightning  24
at Cardinal Stadium, Louisville, KY
Head To Head for:
Memphis vs Louisville
Box Score MEM @ LSV
Sunday, May 15, 2022 - 1:00PM
(8-4) Louisville Lightning  20  vs
(5-7) Pennsylvania Keystones  37
at Beaver Stadium, University Park, PA
Head To Head for:
Louisville vs Pennsylvania
Box Score LSV @ PEN
Sunday, May 22, 2022 - 8:15PM
Sunday Night Football
(9-4) Louisville Lightning  44  vs
(6-7) Birmingham Owls  10
at Protective Stadium, Birmingham, AL
Head To Head for:
Louisville vs Birmingham
Box Score LSV @ BIR
Sunday, May 29, 2022 - 1:00PM
(6-8) Wisconsin Stags  16  vs
(10-4) Louisville Lightning  17
at Cardinal Stadium, Louisville, KY
Head To Head for:
Wisconsin vs Louisville
Box Score WIS @ LSV
Thursday, June 2, 2022 - 8:15PM
Thursday Night Football
(11-4) Louisville Lightning  34  vs
(7-8) Cincinnati Knights  27
at Nippert Stadium, Cincinnati, OH
Head To Head for:
Louisville vs Cincinnati
Box Score LSV @ CIN
Sunday, June 12, 2022 - 1:00PM
(8-8) Toronto Terror  33  vs
(11-5) Louisville Lightning  27
at Cardinal Stadium, Louisville, KY
Head To Head for:
Toronto vs Louisville
Box Score TOR @ LSV
Sunday, June 19, 2022 - 1:00PM
(12-5) Louisville Lightning  38  vs
(3-14) Miami Sol  32
at Hard Rock Stadium, Miami Gardens, FL
Head To Head for:
Louisville vs Miami
Box Score LSV @ MIA
Sunday, June 26, 2022 - 1:00PM
(8-10) Birmingham Owls  30  vs
(12-6) Louisville Lightning  12
at Cardinal Stadium, Louisville, KY
Head To Head for:
Birmingham vs Louisville
Box Score BIR @ LSV
Sunday, July 3, 2022 - 7:30PM
Eastern Conference Wild Card
(12-6) Louisville Lightning  24  vs
(9-9) Toronto Terror  35
at Rogers Centre, Toronto, Ontario
Head To Head for:
Louisville vs Toronto
Box Score LSV @ TOR