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Sunday, September 12, 2021 - 1:00PM
at Nissan Stadium, Nashville, TN
CBS - Tom McCarthy, Aaron Taylor
Sunday, September 19, 2021 - 4:05PM
at State Farm Stadium, Glendale, AZ
FOX - Gus Johnson, Aqib Talib,
Megan Olivi
Sunday, September 26, 2021 - 1:00PM
at TIAA Bank Field, Jacksonville, FL
FOX - Gus Johnson, Aqib Talib,
Megan Olivi
JAX Jamal Agnew returns missed FG 109 yds for TD. 3rd 109 yd return in NFL history.

Sunday, October 3, 2021 - 4:05PM
at SoFi Stadium, Inglewood, CA
FOX - Chris Myers, Daryl Johnston,
Jen Hale
Sunday, October 10, 2021 - 4:25PM
at State Farm Stadium, Glendale, AZ
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin
First start for SF QB Trey Lance. QB Jimmy Garoppolo inactive due to calf injury.
Sunday, October 17, 2021 - 4:05PM
at FirstEnergy Stadium, Cleveland, OH
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin

Sunday, October 24, 2021 - 4:25PM
at State Farm Stadium, Glendale, AZ
CBS - Greg Gumbel, Adam Archuleta,
A.J. Ross
Thursday, October 28, 2021 - 8:20PM
at State Farm Stadium, Glendale, AZ
FOX/NFL Network/Amazon Prime - Joe Buck, Troy Aikman,
Kristina Pink, Erin Andrews, Hannah Storm, Andrea Kremer
Sunday, November 7, 2021 - 4:25PM
at Levis Stadium, Santa Clara, CA
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin

Sunday, November 14, 2021 - 4:05PM
at State Farm Stadium, Glendale, AZ
FOX - Kenny Albert, Jonathan Vilma,
Sara Walsh
Sunday, November 21, 2021 - 4:25PM
at Lumen Field, Seattle, WA
FOX - Kenny Albert, Jonathan Vilma,
Sara Walsh
Sunday, December 5, 2021 - 1:00PM
at Soldier Field, Chicago, IL
FOX - Adam Amin, Mark Schlereth,
Shannon Spake

Monday, December 13, 2021 - 8:15PM
at State Farm Stadium, Glendale, AZ
ESPN - Steve Levy, Brian Griese, Louis Riddick,
Lisa Salters
State Farm Stadium roof open.
Sunday, December 19, 2021 - 1:00PM
at Ford Field, Detroit, MI
FOX - Gus Johnson, Aqib Talib,
Megan Olivi
Saturday, December 25, 2021 - 8:15PM
at State Farm Stadium, Glendale, AZ
NFL Network - Joe Davis, Kurt Warner,
Peter Schrager, Melissa Stark
ARZ clinches playoff berth with LA Rams victory over MIN.

Sunday, January 2, 2022 - 4:25PM
at AT&T Stadium, Arlington, TX
FOX - Joe Buck, Troy Aikman,
Erin Andrews, Tom Rinaldi
Game flexed from original 1PM kickoff.
Sunday, January 9, 2022 - 4:25PM
at State Farm Stadium, Glendale, AZ
FOX
ARZ QB Kyler Murray becomes the first QB in League history to record 70+ TD passes and 20+ rushing TDs in his first 3 seasons.