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Sunday, September 7, 2025 - 1:00PM
(1-0) Arizona Cardinals  20  vs
(0-1) New Orleans Saints  13
at Caesars Superdome, New Orleans, LA
CBS - Tom McCarthy, Ross Tucker, Logan Ryan,
Tiffany Blackmon
First game for NO HC Kellen Moore.
Head To Head for:
Arizona vs New Orleans
Sunday, September 14, 2025 - 4:05PM
(0-2) Carolina Panthers  22  vs
(2-0) Arizona Cardinals  27
at State Farm Stadium, Glendale, AZ
CBS - Spero Dedes, Adam Archuleta,
Aditi Kinkhabwala
Head To Head for:
Carolina vs Arizona
Sunday, September 21, 2025 - 4:25PM
(2-1) Arizona Cardinals  15  vs
(3-0) San Francisco 49ers  16
at Levi's Stadium, Santa Clara, CA
FOX - Adam Amin, Mark Sanchez,
Kristina Pink
SF K Eddy Piniero kicks GW 35 yd FG on the last play of the game.
SF QB Mac Jones starts in place of injured QB Brock Purdy (shoulder, toe).
Head To Head for:
Arizona vs San Francisco
Thursday, September 25, 2025 - 8:15PM
Thursday Night Football
(3-1) Seattle Seahawks  23  vs
(2-2) Arizona Cardinals  20
at State Farm Stadium, Glendale, AZ
Amazon Prime - Al Michaels, Kirk Herbstreit,
Kaylee Hartung
ARZ Rivalries Game
New Rivalries uniform breaks streak of 46 straight games, including preseasons, of ARZ wearing mono-colored uniforms.
SEA K Jason Myers kicks GW 52 yd FG on the last play of the game.
Head To Head for:
Seattle vs Arizona
Sunday, October 5, 2025 - 4:05PM
(1-4) Tennessee Titans  22  vs
(2-3) Arizona Cardinals  21
at State Farm Stadium, Glendale, AZ
CBS - Spero Dedes, Adam Archuleta,
Aditi Kinkhabwala
TENN K Joey Slye kicks GW 29 yd FG on the last play of the game.
Head To Head for:
Tennessee vs Arizona
Sunday, October 12, 2025 - 1:00PM
(2-4) Arizona Cardinals  27  vs
(5-1) Indianapolis Colts  31
at Lucas Oil Stadium, Indianapolis, IN
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
Lucas Oil Stadium roof and window open.
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Arizona vs Indianapolis
Sunday, October 19, 2025 - 4:25PM
(4-1-1) Green Bay Packers  27  vs
(2-5) Arizona Cardinals  23
at State Farm Stadium, Glendale, AZ
FOX - Kenny Albert, Jonathan Vilma,
Jen Hale
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Green Bay vs Arizona
Monday, November 3, 2025 - 8:15PM
Monday Night Football
(3-5) Arizona Cardinals  27  vs
(3-5-1) Dallas Cowboys  17
at AT&T Stadium, Arlington, TX
ESPN - Joe Buck, Troy Aikman,
Lisa Salters, Laura Rutledge
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Arizona vs Dallas
Sunday, November 9, 2025 - 4:05PM
(3-6) Arizona Cardinals  22  vs
(7-2) Seattle Seahawks  44
at Lumen Field, Seattle, WA
CBS - Kevin Harlan, Trent Green,
Melanie Collins
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Arizona vs Seattle
Sunday, November 16, 2025 - 4:05PM
(7-4) San Francisco 49ers  41  vs
(3-7) Arizona Cardinals  22
at State Farm Stadium, Glendale, AZ
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
State Farm Stadium roof open.
ARZ QB Jacoby Brissett sets an NFL record with 47 completions in a single game breaking the old record of 45 (Jared Goff, LAR, 2019 and Drew Bledsoe, NE, 1994).
Head To Head for:
San Francisco vs Arizona
Sunday, November 23, 2025 - 4:05PM
(7-4) Jacksonville Jaguars  27  vs
(3-8) Arizona Cardinals  24  OT
at State Farm Stadium, Glendale, AZ
CBS - Spero Dedes, Adam Archuleta,
Aditi Kinkhabwala
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Jacksonville vs Arizona
Sunday, November 30, 2025 - 1:00PM
(3-9) Arizona Cardinals  17  vs
(7-5) Tampa Bay Buccaneers  20
at Raymond James Stadium, Tampa, FL
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Arizona vs Tampa Bay
Sunday, December 7, 2025 - 4:25PM
(10-3) Los Angeles Rams  45  vs
(3-10) Arizona Cardinals  17
at State Farm Stadium, Glendale, AZ
FOX - Kenny Albert, Jonathan Vilma,
Megan Olivi
State Farm Stadium roof open.
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Los Angeles vs Arizona
Sunday, December 14, 2025 - 1:00PM
(3-11) Arizona Cardinals  20  vs
(9-5) Houston Texans  40
at NRG Stadium, Houston, TX
FOX - Chris Myers, Mark Schlereth,
Jen Hale
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
Head To Head for:
Arizona vs Houston
Sunday, December 21, 2025 - 4:05PM
(6-9) Atlanta Falcons  26  vs
(3-12) Arizona Cardinals  19
at State Farm Stadium, Glendale, AZ
FOX - Jason Benetti, Brady Quinn,
Sarah Kustok
State Farm Stadium roof open.
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
ATL QB Kirk Cousins starts in place of injured QB Michael Penix (knee).
Head To Head for:
Atlanta vs Arizona
Sunday, December 28, 2025 - 1:00PM
(3-13) Arizona Cardinals  14  vs
(6-10) Cincinnati Bengals  37
at Paycor Stadium, Cincinnati, OH
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
ARZ TE Trey McBride breaks the NFL record for single season receptions by a TE with 119 (PHIL Zach Ertz - 116, 2018).
Head To Head for:
Arizona vs Cincinnati
Sunday, January 4, 2026 - 4:25PM
(3-14) Arizona Cardinals  20  vs
(12-5) Los Angeles Rams  37
at SoFi Stadium, Inglewood, CA
FOX - Kenny Albert, Jonathan Vilma,
Megan Olivi
ARZ QB Jacoby Brissett starts in place of injured QB Kyler Murray (foot).
LAR clinches NFC #5 seed.
ARZ HC Jonathan Gannon fired on Monday, January 5.
Head To Head for:
Arizona vs Los Angeles