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Sunday, September 12, 2021 - 1:00PM
at Ford Field, Detroit, MI
FOX - Kevin Kugler, Mark Sanchez,
Laura Okmin
First game for Detroit head coach Dan Campbell
Sunday, September 19, 2021 - 1:00PM
at Lincoln Financial Field, Philadelphia, PA
FOX - Adam Amin, Mark Schlereth,
Shannon Spake
Sunday, September 26, 2021 - 8:20PM
at Levis Stadium, Santa Clara, CA
NBC - Al Michaels, Cris Collinsworth,
Michele Tafoya
GB K Mason Crosby kicks 54 yd GW FG on last play of the game.

Sunday, October 3, 2021 - 4:05PM
at Levis Stadium, Santa Clara, CA
FOX - Adam Amin, Mark Schlereth,
Shannon Spake
Sunday, October 10, 2021 - 4:25PM
at State Farm Stadium, Glendale, AZ
FOX
First start for SF QB Trey Lance. QB Jimmy Garoppolo inactive due to calf injury.

Sunday, October 31, 2021 - 1:00PM
at Soldier Field, Chicago, IL
FOX
Sunday, November 7, 2021 - 4:25PM
at Levis Stadium, Santa Clara, CA
FOX

Sunday, November 21, 2021 - 1:00PM
at TIAA Bank Field, Jacksonville, FL
FOX
Sunday, November 28, 2021 - 4:25PM
at Levis Stadium, Santa Clara, CA
FOX

Sunday, December 12, 2021 - 1:00PM
at Paul Brown Stadium, Cincinnati, OH
CBS
Sunday, December 19, 2021 - 4:05PM
at Levis Stadium, Santa Clara, CA
CBS
Thursday, December 23, 2021 - 8:20PM
at Nissan Stadium, Nashville, TN
NFL Network

Sunday, January 2, 2022 - 4:05PM
at Levis Stadium, Santa Clara, CA
CBS
Sunday, January 9, 2022 - 4:25PM
at SoFi Stadium, Inglewood, CA
FOX