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Sunday, September 11, 2022 - 1:00PM
San Francisco 49ers    vs
Chicago Bears  
at Soldier Field, Chicago, IL
FOX
Head To Head for:
San Francisco vs Chicago
Sunday, September 18, 2022 - 4:05PM
Seattle Seahawks    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
FOX
Head To Head for:
Seattle vs San Francisco
Sunday, September 25, 2022 - 8:20PM
Sunday Night Football
San Francisco 49ers    vs
Denver Broncos  
at Empower Field at Mile High, Denver, CO
NBC
Head To Head for:
San Francisco vs Denver
Monday, October 3, 2022 - 8:15PM
Monday Night Football
Los Angeles Rams    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
ESPN
Head To Head for:
Los Angeles vs San Francisco
Sunday, October 9, 2022 - 4:05PM
San Francisco 49ers    vs
Carolina Panthers  
at Bank of America Stadium, Charlotte, NC
CBS
Head To Head for:
San Francisco vs Carolina
Sunday, October 16, 2022 - 1:00PM
San Francisco 49ers    vs
Atlanta Falcons  
at Mercedes-Benz Stadium, Atlanta, GA
FOX
Head To Head for:
San Francisco vs Atlanta
Sunday, October 23, 2022 - 4:25PM
Kansas City Chiefs    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
FOX
Head To Head for:
Kansas City vs San Francisco
Sunday, October 30, 2022 - 4:25PM
San Francisco 49ers    vs
Los Angeles Rams  
at SoFi Stadium, Inglewood, CA
FOX
Head To Head for:
San Francisco vs Los Angeles
Sunday, November 13, 2022 - 8:20PM
Sunday Night Football
Los Angeles Chargers    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
NBC
Head To Head for:
Los Angeles vs San Francisco
Monday, November 21, 2022 - 8:00PM
International Series
San Francisco 49ers    vs
Arizona Cardinals  
at Estadio Azteca, Mexico City, Mexico
ESPN
Monday Night Football
Head To Head for:
San Francisco vs Arizona
Sunday, November 27, 2022 - 4:25PM
New Orleans Saints    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
FOX
Head To Head for:
New Orleans vs San Francisco
Sunday, December 4, 2022 - 4:05PM
Miami Dolphins    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
FOX
Head To Head for:
Miami vs San Francisco
Sunday, December 11, 2022 - 4:25PM
Tampa Bay Buccaneers    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
FOX
Head To Head for:
Tampa Bay vs San Francisco
Thursday, December 15, 2022 - 8:15PM
Thursday Night Football
San Francisco 49ers    vs
Seattle Seahawks  
at Lumen Field, Seattle, WA
Amazon Prime
Head To Head for:
San Francisco vs Seattle
Saturday, December 24, 2022 - 4:05PM
Washington Commanders    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
CBS
Head To Head for:
Washington vs San Francisco
Sunday, January 1, 2023 - 4:05PM
San Francisco 49ers    vs
Las Vegas Raiders  
at Allegiant Stadium, Paradise, NV
FOX
Head To Head for:
San Francisco vs Las Vegas
Sunday, January 8, 2023 - TBD
Arizona Cardinals    vs
San Francisco 49ers  
at Levis Stadium, Santa Clara, CA
Head To Head for:
Arizona vs San Francisco