Champions:
Super Bowl Champions,
AFC Champions,
NFC Champions,
NFL Champions (1920-69),
AFL Champions (1960-69),
AAFC Champions (1946-49)
Other Leagues: AFL (1926), AFL (1936-37), AFL (1940-41), CFL (1945-present)
Spring Leagues: WFL (1974-75), AAF (2019), XFL (2001, 2020, 2023), USFL (1983-85, 2022-23), UFL (2024-2025)
Other Leagues: AFL (1926), AFL (1936-37), AFL (1940-41), CFL (1945-present)
Spring Leagues: WFL (1974-75), AAF (2019), XFL (2001, 2020, 2023), USFL (1983-85, 2022-23), UFL (2024-2025)
NFL Teams:
ARZ
ATL
BAL
BUF
CAR
CHI
CIN
CLE
DAL
DEN
DET
GB
HOU
IND
JAX
KC
LV
LAC
LAR
MIA
MIN
NE
NO
NYG
NYJ
PHI
PIT
SEA
SF
TB
TEN
WAS
Defunct
H2H
PSH2H
HOF Game
CASG
Kickoff
Thanksgiving
Playoff Bowl
Championships
Super Bowls
Pro Bowls
International Series
Color vs Color
White at Home
Game Officials
Game Officials
Sunday, September 7, 2025 - 4:05PM
(0-1) Seattle Seahawks
 13
at Lumen Field, Seattle, WA
FOX - Joe Davis, Greg Olsen,
Pam Oliver
Sunday, September 14, 2025 - 1:00PM
(0-2) New Orleans Saints
 21
at Caesars Superdome, New Orleans, LA
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
SF QB Mac Jones starts in place of injured QB Brock Purdy (shoulder, toe).
Sunday, September 21, 2025 - 4:25PM
(2-1) Arizona Cardinals
15 vs
(3-0) San Francisco 49ers
 16
at Levi's Stadium, Santa Clara, CA
FOX - Adam Amin, Mark Sanchez,
Kristina Pink
SF K Eddy Piniero kicks GW 35 yd FG on the last play of the game.
SF QB Mac Jones starts in place of injured QB Brock Purdy (shoulder, toe).
Sunday, September 28, 2025 - 4:05PM
(3-1) San Francisco 49ers
 21
at Levi's Stadium, Santa Clara, CA
FOX - Adam Amin, Mark Sanchez,
Kristina Pink
Thursday, October 2, 2025 - 8:15PM
(3-2) Los Angeles Rams
 23 OT
at SoFi Stadium, Inglewood, CA
Amazon Prime - Al Michaels, Brady Quinn, Kirk Herbstreit,
Kaylee Hartung
SF QB Mac Jones starts in place of injured QB Brock Purdy (turf toe).
Sunday, October 12, 2025 - 4:25PM
(5-1) Tampa Bay Buccaneers
 30
at Raymond James Stadium, Tampa, FL
CBS - Jim Nantz, Tony Romo,
Tracy Wolfson
Flexed from original 1PM kickoff.
SF QB Mac Jones starts in place of injured QB Brock Purdy (turf toe).
SF sets an NFL record by not registering an interception in 13 straight games dating back to the 2024 season.
Sunday, October 19, 2025 - 8:20PM
(3-3) Atlanta Falcons
10 vs
(5-2) San Francisco 49ers
 20
at Levi's Stadium, Santa Clara, CA
NBC - Mike Tirico, Cris Collinsworth,
Melissa Stark
SF QB Mac Jones starts in place of injured QB Brock Purdy (turf toe).
Sunday, October 26, 2025 - 1:00PM
(3-4) Houston Texans
 26
at NRG Stadium, Houston, TX
FOX - Kevin Kugler, Daryl Johnston,
Allison Williams
Sunday, November 2, 2025 - 1:00PM
(2-7) New York Giants
 24
at MetLife Stadium, East Rutherford, NJ
CBS - Kevin Harlan, Trent Green,
Melanie Collins
SF QB Mac Jones starts in place of injured QB Brock Purdy (turf toe).
Sunday, November 9, 2025 - 4:25PM
at Levi's Stadium, Santa Clara, CA
FOX - Kevin Burkhardt, Tom Brady,
Erin Andrews, Tom Rinaldi
Sunday, November 16, 2025 - 4:05PM
(3-5) Arizona Cardinals
 
at State Farm Stadium, Glendale, AZ
FOX
Monday, November 24, 2025 - 8:15PM
at Levi's Stadium, Santa Clara, CA
ESPN
Sunday, November 30, 2025 - 1:00PM
(2-6) Cleveland Browns
 
at Huntington Bank Field, Cleveland, OH
CBS
Sunday, December 14, 2025 - 4:25PM
at Levi's Stadium, Santa Clara, CA
FOX
Monday, December 22, 2025 - 8:15PM
(7-2) Indianapolis Colts
 
at Lucas Oil Stadium, Indianapolis, IN
ESPN
Sunday, December 28, 2025 - 8:20PM
at Levi's Stadium, Santa Clara, CA
NBC
Sunday, January 4, 2026
at Levi's Stadium, Santa Clara, CA
Game date/time TBD.
SF Rivalries Game